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Pre-clinical evidence of NOS2 involvement in animal models of MDD
| Pre-clinical evidence | Reference |
|---|---|
| NOS2 inhibitors augment the efficacy of serotonin reuptake inhibitors in the forced swim test. | [169] |
| NOS2 is increased in the hippocampus and cerebral cortex following stress. | [38] |
| NOS2 inhibition results in antidepressant-like effects in rodents. | [219] |
| The dopamine reuptake inhibitor bupropion modulates the NO system. | [220] |
