Table II.

Range of Prediction Errors of CLp Values Obtained When Scaling the CLp of the Hypothetical Drugs Using Either AS0.75 + MF_PBPK-liver (A) or AS0.75 + MF_{PBPK-microsomes} (B) for the Investigated Paediatric Ages Categorized per Drug Property

Low, intermediate and high extraction ratios are defined as ER ≤ 0.3, 0.3 < ER ≤ 0.7 and ER > 0.7. fu = 1 and Kp = 1 correspond to drugs not binding to plasma proteins (fu = 1) that are also in equilibrium between plasma and red blood cells (Kp = 1). HSA bound corresponds to drugs that diffuse into red blood cells to different extents and that bind to HSA to different extents (including fu = 1). AAG bound corresponds to drugs that diffuse into red blood cells to different extents and that bind to AAG to different extents (including fu = 1). HSA, human serum albumin; AAG, alpha-1 acid glycoprotein; AS0.75 + MF_{PBPK_liver}, AS0.75 in combination with a maturation function expressed in percentage of adult unbound intrinsic clearance per gram of liver; AS0.75 + MF_{PBPK_microsomes}, AS0.75 in combination with a maturation function expressed in percentage of adult unbound intrinsic clearance per microgram of microsomes. Colours indicate the PE category, with PE range for all hypothetical drugs lying within ± 30% in green, within ± 50% in orange and including absolute values higher than 50% in red.