Table 3.
Summary of the influence of bezafibrate (50 μM) on NSC, eNP, and NP
| NSC | eNP | NP | ||
|---|---|---|---|---|
| Viability | ↑ (*) | ↑ (*) | ↓ (ns) | |
| ROS level | ↓ (*) | ↓ (*) | ↓ (*) | |
| Mitochondrial membrane potential | ↓ (ns) | ↓ (ns) | ↑ (*) | |
| Total cell number | ↑ (*) | ↑ (*) | ↓ (*) | |
| Protein expression | SDHA | ↓ (ns) | ↑ (*) | ↑ (*) |
| COX-1 | ↑ (ns) | ↑ (*) | ↑ (*) | |
| mtDNA copy number | ND1/SCLO2B1 ratio | ↓ (ns) | ↑ (ns) | ↑ (*) |
| ND5/SERPINA1 ratio | ↓ (ns) | ↓ (ns) | ↑ (*) | |
| Gene expression (fold of change) | NRF1 | ↑ (1.53) | ↑ (1.79) | ↑ (0.79) |
| TFAM | ↓ (− 1.16) | ↓ (− 0.63) | ↑ (0.92) | |
| PPARGC1A | ↑ (6.39) | ↑ (5.45) | ↑ (0.35) | |
| MAP2 | ↓ (− 0.08) | ↓ (−1.71) | ↓ (− 1.01) | |
| DCX | ↑ (1.91) | ↑ (2.28) | ↑ (9.137) | |
| GFAP | ↑ (6.06) | ↑ (3.72) | ↓ (− 1.94) | |
| S100B | ↑ (5.73) | ↑ (4.15) | ↑ (10.89) | |
NSC neural stem cells, eNP early neural progenitors, NP late neural progenitors, ns not significant, ↑ upregulation, ↓ downregulation
*p < 0.05