Table E2.
Differences in lung function (FEV1/FVC ratio) at 24 years between wheeze phenotypes: ANOVA and Tukey HSD test of pairwise comparisons
| ANOVA | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variation source |
df |
Sum square |
Mean square |
F value |
Pr(>F) |
|||||
| Pre-BD FEV1/FVC ratio | Post-BD FEV1/FVC ratio | Pre-BD FEV1/FVC ratio | Post-BD FEV1/FVC ratio | Pre-BD FEV1/FVC ratio | Post-BD FEV1/FVC ratio | Pre-BD FEV1/FVC ratio | Post-BD FEV1/FVC ratio | Pre-BD FEV1/FVC ratio | Post-BD FEV1/FVC ratio | |
| Phenotypes | 5 | 5 | 0.3269 | 0.1527 | 0.06539 | 0.03054 | 14.51 | 8.33 | 6.2E-14 | 9.0E-08 |
| Residual | 1600 | 1358 | 7.482 | 4.977 | 0.00451 | 0.00366 | ||||
| Tukey HSD test | ||||||
|---|---|---|---|---|---|---|
| Pairwise comparison of wheeze phenotypes | Mean Differences |
Significant (P adjusted < .05)? |
95% CI of differences (lower to upper) |
|||
| Pre-BD FEV1/FVC ratio | Post-BD FEV1/FVC ratio | Pre-BD FEV1/FVC ratio | Post-BD FEV1/FVC ratio | Pre-BD FEV1/FVC ratio | Post-BD FEV1/FVC ratio | |
| Midchildhood remitting AND late-childhood onset | 0.01 | −0.01 | No | No | −0.02 to 0.04 | −0.04 to 0.02 |
| Never/infrequent AND late-childhood onset | 0.02 | 0.01 | No | No | 0.00 to 0.04 | −0.02 to 0.03 |
| Preschool remitting AND late-childhood onset | 0.00 | −0.01 | No | No | −0.03 to 0.02 | −0.04 to 0.01 |
| Persistent AND late-childhood onset | −0.03 | −0.03 | No | No | −0.06 to 0.00 | −0.06 to 0.00 |
| School-age onset AND late-childhood onset | 0.00 | 0.00 | No | No | −0.04 to 0.03 | −0.03 to 0.03 |
| Never/infrequent AND midchildhood remitting | 0.01 | 0.02 | No | No | −0.01 to 0.04 | 0.00 to 0.04 |
| Preschool remitting AND midchildhood remitting | −0.01 | 0.00 | No | No | −0.04 to 0.01 | −0.02 to 0.02 |
| Persistent AND midchildhood remitting | −0.03 | −0.02 | Yes | No | −0.06 to 0.00 | −0.05 to 0.01 |
| School-age onset AND midchildhood remitting | −0.01 | 0.01 | No | No | −0.04 to 0.02 | −0.02 to 0.04 |
| Preschool remitting AND never/infrequent | −0.03 | −0.02 | Yes | Yes | −0.04 to −0.01 | −0.03 to −0.01 |
| Persistent AND never/infrequent | −0.05 | −0.04 | Yes | Yes | −0.07 to −0.03 | −0.06 to −0.01 |
| School-age onset AND never/infrequent | −0.03 | −0.01 | Yes | No | −0.05 to 0.00 | −0.03 to 0.02 |
| Persistent AND preschool remitting | −0.02 | −0.02 | No | No | −0.05 to 0.00 | −0.04 to 0.01 |
| School-age onset AND preschool remitting | 0.00 | 0.01 | No | No | −0.03 to 0.03 | −0.01 to 0.04 |
| School-age onset AND persistent | 0.02 | 0.03 | No | No | −0.01 to 0.05 | 0.00 to 0.06 |
Significant differences are in boldface.
FVC, Forced vital capacity; HSD, honestly significant difference.