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a Dose-dependent acute effects (30 min) of ketamine (KET) and effects of a low dose of medetomidine (MED; 0.05 mg/kg, i.p.) on phospho-MAPKT202/Y204. b Number of escape failures before and 24-h after low-dose ketamine (15 mg/kg, i.p.) or medetomidine (0.05 mg/kg, i.p.) in the learned helplessness paradigm. Data are means ± S.E.M. *< 0.05, ***< 0.001 (for statistical analyses and n numbers, see Table S2)
