Figure 2. Oncogenic BCR fusion proteins and cellular signaling cascades.

BCR-ABL, BCR-FGFR1, and BCR-RET all activate STAT, MAPK, and AKT, while BCR-JAK2 only activates the STAT pathway, and signaling by BCR-PDGFRA remains to be elucidated. All drugs shown inhibit the kinase activity of each fusion protein and has been used in patients who are positive for the respective oncogenic fusion.