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(A) Time (24–48 h) and dose-response (0–10 nM) to Aplidin in murine MLO-A5 osteocyte-like cells. Evaluation of the effects of combinations of Aplidin with the caspase 3 inhibitor DEVD (B), Dex (C) and Btz (D) after 48 h treatment. Representative experiments out of two are shown (n = 4–6 per condition). Bars represent means ± SD. *p < 0.05 vs vehicle; lines indicate p < 0.05 for Dex/Btz alone vs Dex/Btz + Aplidin, and Aplidin vs Aplidin + Btz.
