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. 2019 Apr 12;10(28):2709–2721. doi: 10.18632/oncotarget.26831

Figure 3. Aplidin decreases osteoblast viability and function and co-administration of Btz partially prevents these effects.

Figure 3

(A–C) Cell viability and cell death was evaluated in murine OB-6 osteoblastic cells treated with Aplidin (0–10 nM) alone or in combination with Dex or Btz. Representative experiments out of two are shown (n = 4–6 per condition). Mineralization of OB-6 (D–E) and MC-4 (F) cells treated with/without Aplidin in the presence/absence of Btz for 14-21 days evaluated by Alizarin Red staining. Percent change was calculated over cells cultured with osteogenic media (OM) in the absence of Aplidin. Representative experiments out of two are shown (n = 3–4 per condition). Bars represent means ± SD. *p < 0.05 vehicle; lines indicate p values < 0.05 comparing Dex/Btz alone vs Dex/Btz + Aplidin, and Aplidin vs Aplidin + Btz.