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. 2018 Jul 26;5:100022. doi: 10.1016/j.ynpai.2018.07.003

Fig. 4.

Fig. 4

CRMP2 loss of phosphorylation reverses mechanical allodynia following SNI. (A) Paw withdrawal thresholds for sham-injured rats spinally administered (black arrow) with dsRed (empty plasmid), CRMP2 wildtype (WT) or CRMP2 S522A (15 µg/rat; intrathecal; n = 5–6). (B) Summary of data shown in panel (A) plotted as Area Under the Curve (AUC) for 0–72 h. (C) Paw withdrawal thresholds (PWTs) for rats having an SNI injury and spinally administered (black arrow) with empty, CRMP2 or CRMP2 S522A plasmids (15 µg/rat, intrathecal; n = 9–10). (D) Summary of data shown in panel (C) plotted as AUC for 0–72 h. *p < 0.05 compared to empty plasmid. SNI PWTs were measured on the lateral side of the paw.