Fig. 5.

Expression of constitutively phosphorylated CRMP2 induces mechanical allodynia. (A) Paw withdrawal thresholds for naïve rats spinally administered (black arrow) with empty plasmid or CRMP2 S522D plasmids (15 µg/rat; intrathecal; n = 6). (B) Summary of data shown in panel (A) plotted as AUC for 0–48 h. Data is shown as mean ± s.e.m., and was analyzed by non-parametric two-way analysis of variance where time was the within subjects factor and treatment was the between subjects factor (ANOVA; post hoc: Student-Neuman–Keuls); AUCs were compared by Mann-Whitney non-parametric test.