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. 2018 Dec 12;31(1):107–112. doi: 10.1177/1040638718814583

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Figure 1. — Autopsy and histopathology from captive bighorn sheep with bovine viral diarrhea. A. Cecum opened to show necrohemorrhagic typhlitis, case 4. B. Histopathology of colon demonstrating hemorrhagic typhlocolitis from case 4 with full-thickness hemorrhage and mucosal necrosis. H&E. 20×. C. Immunohistochemistry (IHC) of panel B; positive staining for bovine viral diarrhea virus (BVDV) in mucosal epithelium and submucosal fibroblasts. BVDV IHC. 200×. D. Rumen opened to show necrohemorrhagic rumenitis, case 5. E. Immunohistochemistry of lung from case 6 showing diffuse staining of perivascular smooth muscle and fibroblasts, as well as a few scattered lymphocytes and macrophages. BVDV IHC. 200×. F. Suffusive hemorrhage on ruminal serosa, case 2.