Table 1. Comparison of ex vivo VBA-M and tract based connectivity maps based on a reference atlas [18] providing anatomical regions and associated tract densities (TD) for 332 ROIs.
| Abbrev. | Cluster ∩ ROI | Cluster ∩ ROI (% ROI) |
Max TD (AU) |
Median TD (AU) | Cluster ∩ Network (% Cluster) | Cluster ∩ Network (% Network) | >80 percentile of TD |
|---|---|---|---|---|---|---|---|
| (% Cluster) | |||||||
| M1 | 6.85 | 13.23 | 1.27E+08 | 7300.78 | 89.11 | 2.82 | 37.23 |
| M2 | 0.59 | 1.07 | 7.81E+07 | 3855.64 | 84.69 | 2.65 | 26.2 |
| S1 | 0.53 | 9.28 | 1.29E+08 | 10904.67 | 83.65 | 2.71 | 32.75 |
| CPu | 14.17 | 10.06 | 8.97E+07 | 3195.99 | 82.18 | 1.58 | 25.89 |
| S1BF | 9.23 | 15.46 | 6.05E+07 | 9155.23 | 79.3 | 2.94 | 40.48 |
| V1M | 0.08 | 0.28 | 9.97E+07 | 6929.78 | 77.67 | 2.51 | 26.56 |
| S1FL | 3.91 | 15.82 | 1.42E+08 | 2899.99 | 77.52 | 3.6 | 26.18 |
| AuD | 1.71 | 16.46 | 5.01E+07 | 8671.08 | 77.5 | 2.72 | 26.21 |
| V1 | 0.14 | 3.79 | 3.16E+07 | 4064.39 | 77.46 | 2.4 | 21.61 |
| S2 | 11.22 | 31.16 | 1.24E+08 | 18128.94 | 75.49 | 2.87 | 35.05 |
| S1HL | 5.96 | 31.28 | 8.22E+07 | 2775.28 | 75.24 | 4.3 | 29.12 |
| V2L | 2.46 | 5.32 | 4.40E+07 | 4589.09 | 74.78 | 2.47 | 21.44 |
| S1UL | 11.81 | 35.96 | 1.54E+08 | 8640.17 | 73.4 | 3.43 | 32.73 |
| Pir | 6.09 | 1.73 | 1.59E+07 | 412.1 | 73.01 | 1.6 | 20.92 |
| TeA | 0.03 | 0.14 | 4.68E+07 | 3821.42 | 70.91 | 2.07 | 20.27 |
| Ins | 3.68 | 3.24 | 2.54E+07 | 1399.28 | 69.77 | 2.3 | 19.61 |
| Ect | 0.04 | 0.13 | 6.59E+07 | 3809.28 | 68.91 | 2.08 | 20.8 |
| AuV | 1.16 | 5.18 | 4.44E+07 | 5253.91 | 68.78 | 2.68 | 23.11 |
| V1B | 2.32 | 16.43 | 2.26E+07 | 3044.9 | 68.46 | 2.59 | 19.4 |
| PRh | 0.46 | 3.76 | 7.05E+07 | 3521.97 | 66 | 2.19 | 19.29 |
| Au1 | 1.85 | 3.27 | 4.12E+07 | 3772.89 | 63.81 | 2.3 | 17.02 |
| S1Tr | 0.13 | 3.22 | 3.02E+07 | 4649.03 | 61.35 | 5.36 | 17.64 |
| GP | 0.38 | 0.74 | 3.74E+07 | 3484.7 | 59.11 | 1.57 | 14.3 |
| S1DZ | 0.42 | 4.33 | 3.66E+08 | 6821.74 | 56.64 | 5.04 | 11.93 |
| Amy | 7.35 | 8.04 | 3.36E+07 | 511.08 | 54.01 | 1.31 | 15.07 |
| VPal | 0.96 | 0.15 | 8.61E+07 | 3464.94 | 53.24 | 1.34 | 15.02 |
| ot | 0.75 | 0.29 | 2.71E+08 | 6826.12 | 52.93 | 1.55 | 11.76 |
| S1J | 0.91 | 4.25 | 9.03E+08 | 6278.1 | 51.08 | 4.28 | 12.68 |
| VCl | 1.46 | 0.84 | 1.96E+08 | 10967.93 | 47.5 | 2.25 | 10.51 |
| DLEnt | 1.42 | 2.29 | 7.10E+07 | 2564.6 | 46.05 | 2.16 | 12.32 |
| Preopt | 0.03 | 0.07 | 3.19E+07 | 990.39 | 43.29 | 1.05 | 11.1 |
| Hyp | 0.14 | 0.24 | 1.86E+07 | 762.85 | 41.6 | 1.01 | 7.56 |
| DCl | 0.53 | 3.38 | 4.58E+08 | 19983.45 | 40.93 | 2.57 | 9.53 |
| S1Sh | 0.01 | 1.23 | 6.84E+07 | 4307.68 | 40.01 | 5.1 | 7.13 |
| cc | 1.21 | 0.55 | 7.07E+07 | 2143.26 | 37.09 | 1.13 | 7.55 |
The left most column shows the atlas regions (abbreviations) intersected by significant clusters identified by ex vivo VBA-M. The percentage of the total cluster found in each atlas region was highest (14%) for the CPu, followed by S1/S2 (~ 10%), and M1 (7%). The percentage of atlas regions covered by the VBA-M clusters was >30% for S1/S2, and >10% for M1 and CPu. We estimated the median and maximum tract density for the overlap between clusters and atlas regions, and the percentage cluster in individual networks, with respect to the size of the cluster, and the size of the network. More than 80% of the clusters were found to overlap with networks for M1, M2, S1, although these clusters occupied a small percentage of the extensive connectivity maps for these regions. The number of significant voxels in the upper 80th percentile for the individual tract density maps was ~40% for M1/S1. Abbreviations: M1: primary motor cortex, M2: secondary motor cortex, S1 primary somatosensory cortex, CPu: caudate putamen, BF: barrel field, V1M: primary visual cortex (monocular), FL: forelimb; AuD: auditory cortex; S2: secondary somatosensory cortex; HL: hind limb; UL: upper lip; V2: secondary visual cortex; Pir: piriform; TeA: temporal association area; Ins: insula; Ect: ectorhinal cortex; PRh: perirhinal cortex; Tr: trunk; GP: globus pallidus; DZ: dysgranular; Amy: amygdala; J: jaw; Cl: ventral claustrum; DLEnt: dorsolateral entorhinal cortex; Preot: preoptic; Hyp: hypothalamus; DCl: dorsal claustrum; Sh: shoulder; cc: corpus callosum.