Table 1. Kinase inhibition profile of compound 1 at 50 μM.
Kinase | % Inhib. | Kinase | % Inhib. |
---|---|---|---|
ABL1 | 0 | mTOR | 4 |
AURKA | 22 | PDGFRB | 21 |
AURKB | 7 | RET | 15 |
AURKC | 2 | RET (M918T) | 28 |
BRAF | 9 | RET (V804L) | 35 |
CSF1R | 3 | S6K1 | 0 |
FGFR | 0 | SRC | 5 |
FLT3 | 52 | TTK | 17 |
Bold, inhibited by more than 40%.