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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Mitochondrion. 2019 Apr 10;46:22–29. doi: 10.1016/j.mito.2019.04.001

Figure 2: In vivo TRAP–UFP exposure impairs mitochondrial function and increases MDP levels in murine liver.

Figure 2:

C57Bl/6 male mice were exposed to TRAP–UFP or Control air for 10 weeks and liver was collected to examine the mitochondrial function, mtDNAcn, mtDNA oxidation and MDP levels. (A) TRAP–UFP exposure decreased mitochondrial oxygen consumption rate in ex vivo hepatic explants measured by Seahorse XF96 Analyzer (p<0.01). (B) Mitochondrial copy number in liver measured by qPCR decreased with TRAP–UFP exposure after 10 week exposure (p<0.01). TRAP–UFP increased HN (C), did not affect MOTS–C (D) and increased SHLP2 (E) levels in liver (p<0.01).