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Performance of the C3d assay and intragraft C4d detection in predicting graft loss at 1, 2, and 3 years post allograft dysfunction. GL, graft loss.
| Assay | Test Performance | GL 1st year | GL 2nd year | GL 3rd year |
|---|---|---|---|---|
| C3d test | Sensitivity | 100% | 85% | 83% |
| Specificity | 30% | 28% | 27% | |
| Positive predictive value | 26% | 36% | 41% | |
| Negative predictive value | 100% | 80% | 72% | |
| Intragraft C4d | Sensitivity | 83% | 70% | 67% |
| Specificity | 42% | 41% | 40% | |
| Positive predictive value | 24% | 33% | 38% | |
| Negative predictive value | 92% | 76% | 68% |
