Table 3.

Univariate and multivariable Cox proportional hazards models for overall survival (n=82; 31 deaths)^a

Variable	HR	95% CI	p
Univariate
Age	0.99	0.95–1.02	0.46
Sex (male vs female)	0.85	0.39–1.84	0.68
White blood cell count	1.02	1.00–1.04	0.12
Hemoglobin	0.91	0.80–1.03	0.14
Platelet count	1.00	1.00–1.00	0.81
Albumin	0.61	0.31–1.17	0.14
Lactate dehydrogenase	1.00	1.00–1.00	0.48
Ferritin	1.04	1.01–1.07	0.02
B2-microglobulin	0.99	0.85–1.15	0.90
Absolute neutrophil count	1.05	1.01–1.08	0.02
Basophils	1.05	0.96–1.14	0.27
Eosinophils	1.01	0.94–1.09	0.72
Hepatomegalya	1.24	0.37–4.18	0.73
Splenomegalya	0.94	0.40–2.23	0.89
Hypomethylating agentsb	1.20	0.47–3.05	0.70
Chemotherapyb	1.46	0.50–4.24	0.49
Bone marrow fibrosis (grade 2 vs 0/1)	2.55	1.18–5.52	0.02
IPSS cytogenetic (Intermediate vs. Poor)	0.55	0.16–1.83	0.33
IPSS cytogenetic (Good or Very Good vs. Poor)	0.29	0.10–0.91	0.03
Circulating blasts	1.00	0.87–1.16	0.97
Bone marrow blasts	0.98	0.90–1.06	0.58
Bone marrow cellularity	1.01	0.99–1.04	0.27
Bone marrow monocytes	1.00	0.95–1.05	0.98
Ringed sideroblasts	1.00	0.98–1.02	0.82
Multivariable
Absolute neutrophil count	1.06	1.02–1.11	0.008
Bone marrow fibrosis (grade 2 vs 0/1)	1.06	1.02–1.11	0.008
IPSS cytogenetic (Intermediate vs. Poor)	0.23	0.06–0.98	0.008
IPSS Cytogenetic (Good or Very Good vs. Poor)	0.23	0.07–0.73	0.01

^aCategorical variable (compared with absence of condition).

^bCompared with no therapy.

Abbreviations: HR, hazard ratio; CI, confidence interval.