Figure 2.

Mutation Frequencies

(A–C) De novo mutation numbers identified for substitutions (A), double-substitutions (B), and indels (C). Asterisks indicate a significant increase in mutations over controls (STAR Methods). ^∗∗q value ≤ 0.01; ^∗∗∗q value ≤ 0.001 (permutation test). Data are for 2–4 independent subclone experiments. Bars represent mean ± SEM of subclone observations.

(D) For treatments with a significant increase in mutations, mutagenicity index = (N_treatment − N_control)/N_control, where N_treatment is the average mutation number of treatment subclones and N_control is the average mutation number of control subclones.

See also Tables S2 and S3.