Mutation Frequencies
(A–C) De novo mutation numbers identified for substitutions (A), double-substitutions (B), and indels (C). Asterisks indicate a significant increase in mutations over controls (STAR Methods). ∗∗q value ≤ 0.01; ∗∗∗q value ≤ 0.001 (permutation test). Data are for 2–4 independent subclone experiments. Bars represent mean ± SEM of subclone observations.
(D) For treatments with a significant increase in mutations, mutagenicity index = (Ntreatment − Ncontrol)/Ncontrol, where Ntreatment is the average mutation number of treatment subclones and Ncontrol is the average mutation number of control subclones.
See also Tables S2 and S3.