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Substitution Signatures
(A) Mutational profile of all controls. It is a 96-channel vector (6 types of substitution ∗ 4 types of 5′ base ∗ 4 types of 3′ base). Mean ± SEM of 35 subclones. This is also the background signature seen in all treatments.
(B) Signatures identified from 53 treatments. Blue indicates a less stable signature (less consistent in subclones due to low numbers).
(C) Hierarchical clustering of the 53 signatures.
