Figure 5.
Indel Signatures
(A) Indel profile of controls. Due to low numbers, all control subclones are aggregated to obtain a more accurate indel profile (see Figure S4).
(B) Profiles of eight mutagens (10 treatments). Blue indicates less stable signature.
(C) High resolution profile of cisplatin (12.5 μM)-induced one-base T insertion in repetitive sequence, taking 5′ sequence context into account.
(D) High resolution profile of DBADE-induced T and C insertions.
(E) Cosine similarities between ten mutagen, smoking-associated lung, and control signatures.