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. Author manuscript; available in PMC: 2020 May 7.
Published in final edited form as: Cell Metab. 2019 Jan 31;29(5):1135–1150.e6. doi: 10.1016/j.cmet.2019.01.002

Figure 1. Mouse models of HCC with CTNNB1 mutations display simultaneous positivity for GS and p-mTOR-S2448.

Figure 1.

A. IHC on serial liver sections shows same tumor foci to be positive for GS and p-mTOR-S2448 in the Met-β-catenin, Kras-β-catenin and Nrf2-β-catenin models (50×). Cholangiocarcinoma (CCA) occurring in Kras-β-catenin model are negative. IHC on serial sections also shows hepatoblastoma (HB) to be positive for GS and p-mTOR-S2448 in Yap-β-catenin model (50×).

B. IHC on serial liver sections shows same tumor foci to be negative for GS and p-mTOR-S2448 in the Met-WT-β-catenin HCC model generated by co-expressing wild-type non-mutant β-catenin and c-Met (50×).