A. Serial sections from a normal human (top) and mouse (bottom) liver stained for GS and p-mTOR-S2448 show positive staining for both only in the zone 3 hepatocytes (50×).
B. Representative IHC shows staining in zone-3 hepatocytes of GS and p-mTOR-S2448 in β-cateninfl/fl mice (top), which was absent in Alb-Cre/β-cateninfl/fl (bottom) (100×).
See also Figures S4 and S7