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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Hypertension. 2019 Jun;73(6):1266–1274. doi: 10.1161/HYPERTENSIONAHA.119.12832

Figure 3. DOCA-salt-induced dysautonomia is attenuated in mice with ADAM17 knockdown in glutamatergic neurons.

Figure 3.

(A-C) Autonomic function was assessed pharmacologically by determining the changes in MAP (ΔMAP) and heart rate (ΔHeart Rate) after intraperitoneal injections of a β-blocker (A, propranolol, 4 mg/kg), a ganglionic blocker (B, chlorisondamine, 2.5 mg/kg), and a muscarinic antagonist (C, atropine, 1 mg/kg), n=10 mice/group. (D) Ejection fraction, representing cardiac systolic function, was measured in DOCA-salt or sham-treated mice (n=8 mice/group), by echocardiography. (E) Aorta sections were stained with H&E and the media thickness was quantified using Image J (n=6 mice/group). Data are shown as mean ±SEM. Statistical significance: Two-way ANOVA: *P<0.05, **P<0.01, ***P<0.001 vs. respective baselines or shams; †P<0.05 vs. control+DS. DS: DOCA-salt.