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. Author manuscript; available in PMC: 2020 May 7.
Published in final edited form as: Structure. 2019 Mar 21;27(5):816–828.e4. doi: 10.1016/j.str.2019.03.001

Figure 1. Overall structure of the chimeric RIα2:J-PKAcα2 holoenzyme.

Figure 1.

(A) Domain organization and color coding of J-PKAcα and RIα subunits.

(B) Structure of the holoenzyme. One heterodimer is labeled as RIα:J-PKAcα and its two-fold symmetry mate is labeled as RIα’:J- PKAcα’. The two-fold axis position is shown as a solid black circle.

(C) B factor analysis of the holoenzyme.

(D) The J-domain is in close proximity to the CNB-B domain of RIα.