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. Author manuscript; available in PMC: 2020 May 8.
Published in final edited form as: Chem Rev. 2019 Apr 12;119(9):6086–6161. doi: 10.1021/acs.chemrev.8b00608

Figure 14.

Figure 14

Membrane partitioning and the facilitated binding of anesthetics to the modulation sites of GLIC during the flooding simulations. (A) Time series demonstrating the membrane partitioning of desflurane during the flooding simulations, in which a high copy number of drug molecules were initially placed randomly in solution. (B) Spontaneous binding of desflurane to the membrane domains of GLIC, following its rapid partitioning into the membrane. The desflurane molecule forms several non-specific contacts within the binding site (top inset), which is located near the same region within the membrane where desflurane partitions (bottom inset). Reprinted with permission from ref 269. Copyright 2016 Elsevier.