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. Author manuscript; available in PMC: 2020 May 8.
Published in final edited form as: Chem Rev. 2019 Apr 12;119(9):6086–6161. doi: 10.1021/acs.chemrev.8b00608

Figure 22.

Figure 22

Representative integral membrane receptors covered in Section 3.3. The receptors shown from left to right are β2 adrenergic receptor (PDB:2RH1), a G-protein coupled receptor; the epidermal growth factor receptor (EGFR), (assembled using the transmembrane domain from PDB:5LV6, and the kinase domain from PDB:2JIT), which is associated with diseases such as Alzheimer’s; bovine rhodopsin (PDB:1U19), a photoreceptor required for vision; and the integrin (PDB:2K9J) involved in the key signal transduction pathways in the cell.