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. Author manuscript; available in PMC: 2020 May 8.
Published in final edited form as: Chem Rev. 2019 Apr 12;119(9):6086–6161. doi: 10.1021/acs.chemrev.8b00608

Figure 25.

Figure 25

Binding of EGFR kinase to the anionic membrane. (A) Electrostatic potential surface of the kinase domain (KD) when in contact with the membrane. The electrostatic potential is from −5 to 5 kB T/e (red to blue). (B) KD interactions with the lipid bilayer and the aggregation of anionic lipids (PS in red) captured from μs-long MD simulations. The KD is attached to the membrane, and the active sites (shown in orange) are sequestered by the membrane except in the active dimer. Reprinted with permission from ref 434. Copyright 2013 Elsevier.