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. Author manuscript; available in PMC: 2020 May 8.
Published in final edited form as: Chem Rev. 2019 Apr 12;119(9):6086–6161. doi: 10.1021/acs.chemrev.8b00608

Figure 26.

Figure 26

Representative peripheral proteins discussed in Section 4. Ras proteins are key regulators in cell signaling (globular domain (PDB:4OBE), linker was modeled using Rosetta). PH domain (PDB:1UNQ), a PIP binding domain found in signaling proteins. Coagulation factor X GLA domain (PBD:1IOD) is a Ca2+-coordinating domain used by coagulation proteins to bind anionic membranes. Cytochrome P450 enzymes are crucial to metabolism and biosynthesis (globular domain (PDB:1TQN), the transmembrane helix was modeled using Modeller).