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. Author manuscript; available in PMC: 2020 May 8.
Published in final edited form as: Chem Rev. 2019 Apr 12;119(9):6086–6161. doi: 10.1021/acs.chemrev.8b00608

Figure 27.

Figure 27

Results of spontaneous bilayer formation and protein-membrane association from CG simulations of nine monotopic membrane-associated enzymes, and comparison of their binding mode and depth. From right to left, and top column to bottom, these enzymes are: COX-1 (cyclooxygenase 1); ACO (apocarotenoid cleavage oxygenase); fatty acid amide hydrolase (FAAH); COX-2 (cyclooxygenase 1); P450 (cytochrome P450); 11-β-HSD (11-β-hydroxysteroid dehydrogenase); OSC (oxidosqualene cyclase); SHC (squalene hopene cyclase); CrAT (carnitine acyltransferase). Reprinted with permission from ref 454. Copyright 2009 American Chemical Society.