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. Author manuscript; available in PMC: 2020 May 8.
Published in final edited form as: Chem Rev. 2019 Apr 12;119(9):6086–6161. doi: 10.1021/acs.chemrev.8b00608

Figure 29.

Figure 29

Membrane bound conformation of phospholipases, and the critical reactions they catalyze. Membrane binding of (A) phospholipase A2 (PLA2). Important membrane-binding residues shown in blue, red, and green. Reprinted with permission from ref 470. Copyright 2013 Bucher et al. Licensed under a Creative Commons Attribution 4.0 International License. The PLA2 reaction is provided underneath the figure. (B) Phospholipase C (PLC) bound to membrane bilayer, higlighting cation-π interactions with PLC anchor residues. Reprinted with permission from ref 471. Copyright 2013 American Chemical Society. The PLC reaction is provided underneath the figure.