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. Author manuscript; available in PMC: 2020 May 8.
Published in final edited form as: Chem Rev. 2019 Apr 12;119(9):6086–6161. doi: 10.1021/acs.chemrev.8b00608

Figure 30.

Figure 30

Binding modes of (A) GDP-bound and (B) GTP-bound G-domain of H-Ras observed by CG simulations. The GDP-bound G-domain bound in an approximately perpendicular orientation to the plane of the membrane, while the GTP-bound G-domain bound in a semi-parallel orientation. These distinct orientations can be observed from the positions of α-helix 4 (α4) and α-helix 5 (α5) with respect to the membrane. Reprinted with permission from ref 520. Copyright 2013 Li et al. Licensed under a Creative Commons Attribution 4.0 International License.