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. Author manuscript; available in PMC: 2020 May 8.
Published in final edited form as: Chem Rev. 2019 Apr 12;119(9):6086–6161. doi: 10.1021/acs.chemrev.8b00608

Figure 32.

Figure 32

Membrane budding caused by α synuclein. (A) Top-down view of the spoke starting configuration. The system includes 48 α synuclein proteins (yellow) and a pure POPG lipid bilayer (blue). The N-terminus of each protein is marked with a black dot. (B) Snapshot at 300 ns simulation time. The budding tubule extends 25 nm above the bulk lipid bilayer. Reprinted with permission from ref 558. Copyright 2014 American Chemical Society.