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. Author manuscript; available in PMC: 2020 May 8.
Published in final edited form as: Chem Rev. 2019 Apr 12;119(9):6086–6161. doi: 10.1021/acs.chemrev.8b00608

Figure 35.

Figure 35

Representative conformations of Aβ tetramer and tetramer-membrane interactions. The images represent the central structure of the largest cluster from the last 250 ns of each simulation, with percentages representing the cluster size (percentage of frames belonging to the cluster). Aβ tetramer binding significantly perturbed POPC membranes, whereas the cholesterol-rich membrane remained relatively unperturbed. Reprinted with permission from ref 634. Copyright 2016 Elsevier.