Figure 42.

Putative PS binding sites for coagulation factor X GLA domain (FX-GLA). Ca²⁺ ions are shown in green, and specialized GLA residues (marked as γ) are shown in gold. The GLA domain membrane binding loop is shown in magenta, hydrophobic residues which insert into the core of the membrane are shown in cyan, and the rest of the protein is shown in silver. Lipids are shown with carbon atoms in light pink, nitrogen in blue, and oxygen in red. (A) Spontaneous binding of FX-GLA domain to an HMMM bilayer. ¹⁸⁹ (B-C) Putative PS–specific binding sites. Sites identified as most likely to be PS specific because all three charged groups of the PS lipid interact with the protein simultaneously. ¹⁸⁹ Adapted with permission from ref 189. Copyright 2017 John Wiley and Sons.