Skip to main content
. Author manuscript; available in PMC: 2020 May 8.
Published in final edited form as: Chem Rev. 2019 Apr 12;119(9):6086–6161. doi: 10.1021/acs.chemrev.8b00608

Figure 44.

Figure 44

CDL mediated formation of respiratory supercomplexes. (A) View of the CDL-containing system after 20 μs self-assembly CG simulation. CDL and POPC are shown in green and grey, respectively. Cytochrome bc1 (complex III, CIII) and Cytochrome CcO (complex IV, CIV) are colored as in (B). (B) A snapshot at the end of the simulation showing the lipid content at the bc1/CcO interface. (C) Schematic model of CDL implication in the formation of the supercomplexes. The presence of CDL (green dots) increases the contacts between bc1 and CcO. Two copies of NADH dehydrogenase (complex I, CI) are shown to illustrate its possible integration to the bc1/CcO supercomplexes formed during the simulations. Adapted with permission from ref 441. Copyright 2016 The Royal Society of Chemistry.