(A) Effects of mTOR signaling on bacterial food intake. Inhibition of mTORC1-specific genes did not affect feeding, and the small increase seen with let-363 RNAi might reflect inhibition of the related but distinct complex mTORC2 (Saxton and Sabatini, 2017), as suggested by the effect of rict-1 (Rictor) RNAi.
(B) Tissue-specific activities of DAF-16 in the regulation of food intake. DAF-16 is expressed from transgenes in the intestine (ges-1) or neurons (unc-119), or from its own promoter (Pdaf-16) (Libina et al., 2003).
Mean ± SEM, two-tailed t-test. * P < 0.05, ** P < 0.01, *** P < 0.0001.