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. 2019 Feb 26;37(14):1169–1178. doi: 10.1200/JCO.18.00925

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© 2019 by American Society of Clinical Oncology

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FIG 2. — Association of cell cycle pathway gene expression and the efficacy of palbociclib (PAL) in combination with fulvestrant (FUL). Expression of cell cycle pathway genes dichotomized by median expression, with hazard ratios (HRs) for progression-free survival of PAL plus FUL versus placebo (PBO) plus FUL. HRs were derived from a Cox proportional hazards regression model. Interaction P value for statistical interaction between gene expression and treatment. CCND1, cyclin D1; CCND3, cyclin D3; CCNE1, cyclin E1; CCNE2, cyclin E2; CDK2, cyclin-dependent kinase 2; CDK4, cyclin-dependent kinase 4; CDK6, cyclin-dependent kinase 6; CDKN2A, cyclin-dependent kinase inhibitor 2A; ESR1, estrogen receptor 1; FDR, false discovery rate; RB1, retinoblastoma 1.