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Intrinsic molecular subtype and efficacy of palbociclib (PAL). (A) Intrinsic subtype distribution of tumors in the PALOMA-3 trial. (B) Progression-free survival (PFS) in luminal A (LumA) and B (LumB) tumors. (C) Cyclin E1 (CCNE1) mRNA expression by intrinsic molecular subtype. BasalL, basal-like; FUL, fulvestrant; HER2E, human epidermal growth factor receptor 2–enriched; HR, hazard ratio; mPFS, median progression-free survival; NormL, normal-like; PBO, placebo.
