Table 2. Mutation frequencies of the top 25 pan-cancer candidate genes in each tumour type (percentages of discovery samples).
| Gene | Breast | Colorectal | Head & Neck | Kidney clear cell | Lung Adeno | Lung Squamous | Ovarian | Melanoma | Thyroid | Uterus | Pan-cancer | Weighted pan-cancer |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TP53 | 25.2 | 44.5 | 47.1 | 1.6 | 42.9 | 68.4 | 55.6 | 13.5 | 0.0 | 16.1 | 30.7 | 38.0 |
| KRAS | 0.3 | 44.1 | 0.0 | 0.5 | 30.0 | 0.8 | 0.0 | 1.1 | 2.7 | 21.7 | 15.2 | 13.7 |
| PIK3CA | 31.3 | 45.6 | 11.8 | 2.7 | 5.0 | 9.8 | 0.0 | 2.2 | 0.0 | 51.1 | 22.3 | 20.9 |
| PTEN | 2.4 | 35.7 | 2.9 | 2.2 | 1.7 | 7.5 | 0.0 | 6.7 | 0.0 | 57.8 | 15.0 | 11.2 |
| VHL | 0.0 | 14.7 | 0.0 | 41.1 | 0.0 | 0.8 | 0.0 | 1.1 | 0.0 | 1.1 | 7.7 | 4.5 |
| FBXW7 | 0.3 | 28.7 | 5.9 | 0.5 | 2.9 | 6.8 | 0.0 | 3.4 | 0.0 | 18.3 | 8.7 | 8.4 |
| CDH1 | 5.4 | 15.4 | 2.9 | 0.5 | 0.8 | 0.8 | 0.0 | 2.2 | 0.0 | 3.9 | 4.7 | 4.9 |
| CDH10 | 0.3 | 9.6 | 16.2 | 1.1 | 17.1 | 17.3 | 0.0 | 14.6 | 0.0 | 11.1 | 8.8 | 10.1 |
| SMAD4 | 0.0 | 28.7 | 1.5 | 0.0 | 3.3 | 2.3 | 0.0 | 0.0 | 0.0 | 2.2 | 6.0 | 6.3 |
| DCAF4L2 | 1.0 | 7.4 | 5.9 | 0.0 | 8.3 | 4.5 | 0.0 | 4.5 | 0.0 | 4.4 | 4.2 | 4.7 |
| CTNNB1 | 0.3 | 19.5 | 1.5 | 0.5 | 3.8 | 1.5 | 0.0 | 3.4 | 0.0 | 30.6 | 8.0 | 6.0 |
| OR2M3 | 0.0 | 5.9 | 0.0 | 0.0 | 5.8 | 3.8 | 0.0 | 10.1 | 2.7 | 6.7 | 3.7 | 2.9 |
| FAM47A | 0.7 | 4.8 | 2.9 | 0.5 | 9.2 | 7.5 | 0.0 | 14.6 | 1.4 | 6.1 | 4.8 | 4.4 |
| FAM5C | 0.7 | 8.8 | 5.9 | 3.2 | 11.7 | 12.0 | 3.7 | 21.3 | 0.0 | 5.0 | 7.0 | 6.8 |
| PIK3R1 | 0.7 | 9.6 | 1.5 | 0.5 | 1.3 | 1.5 | 0.0 | 4.5 | 0.0 | 38.3 | 6.9 | 4.3 |
| ZNF676 | 0.0 | 3.3 | 5.9 | 0.5 | 9.2 | 11.3 | 0.0 | 20.2 | 0.0 | 3.3 | 4.8 | 4.9 |
| APC | 0.3 | 77.6 | 1.5 | 0.5 | 3.3 | 3.0 | 0.0 | 6.7 | 0.0 | 13.9 | 16.5 | 16.0 |
| KLHL4 | 0.3 | 8.1 | 7.4 | 0.5 | 8.3 | 5.3 | 0.0 | 9.0 | 1.4 | 7.2 | 5.0 | 5.4 |
| WBSCR17 | 1.4 | 10.3 | 0.0 | 0.5 | 7.5 | 3.8 | 0.0 | 11.2 | 0.0 | 6.1 | 4.9 | 4.2 |
| PRDM9 | 0.3 | 8.8 | 4.4 | 0.5 | 12.5 | 6.8 | 0.0 | 16.9 | 4.1 | 9.4 | 6.6 | 6.1 |
| TPTE | 0.3 | 7.0 | 4.4 | 0.0 | 13.3 | 10.5 | 0.0 | 23.6 | 0.0 | 8.9 | 6.8 | 6.2 |
| PCDH11X | 0.7 | 7.7 | 5.9 | 2.2 | 15.8 | 15.0 | 3.7 | 7.9 | 2.7 | 7.2 | 7.2 | 7.2 |
| MAGEC1 | 0.3 | 7.7 | 5.9 | 1.1 | 9.2 | 9.8 | 0.0 | 15.7 | 1.4 | 9.4 | 6.1 | 5.8 |
| EGFR | 0.3 | 15.1 | 4.4 | 0.5 | 10.4 | 2.3 | 0.0 | 6.7 | 0.0 | 2.2 | 5.4 | 5.8 |
| FAM47C | 2.0 | 5.9 | 2.9 | 1.1 | 12.5 | 3.8 | 3.7 | 12.4 | 0.0 | 7.2 | 5.5 | 5.1 |