Figure 8. Relative trends of morphological factors, intracellular protein levels and cell functions with respect to the nanotopographical densities.
(A) Illustrative summary of cellular responses on various nanopatterned surfaces. (B) Trends of morphological index according to the nanotopographical density such as cell body elongation, nuclear elongation, CSI [(area)/(perimeter)2] and a reciprocal of CSI [(perimeter)2/(area)]. (C) Trends of intracellular proteins for cell-substrate interaction (integrin β1) and cell-cell interaction (N-cadherin). (D) Relative trends of osteogenesis, neurogenesis, migration, and proliferation according to the pattern density. All values obtained in this study were normalized from 0 and 1.