Table 3.
Effect of indomethacin (IndoM) on brush border membrane enzymes in different tissue homogenates.
| Groups | ALP (μmol/ mg protein/ h) | GGTase (μmol/ mg protein/ h) | LAP (μmol/ mg protein/ h) | ACP (μmol/ mg protein/ h) | Sucrase (μmol/ mg protein/ h) |
|---|---|---|---|---|---|
| Cortex | |||||
| Control | 2.07±0.05 | 49.50±2.10 | 7.04±0.04 | 2.74±0.14 | |
| IndoM | 1.15±0.06* (−44%) | 38.80±1.74* (−22%) | 5.42±0.07* (−23%) | 1.95±0.27* (−29%) | |
| Medulla | |||||
| Control | 3.10±0.02 | 52.40±0.32 | 1.13±0.02 | 1.92±0.07 | |
| IndoM | 2.02±0.01* (−35%) | 40.90±1.16* (−22%) | 0.82±0.04* (−27%) | 1.64±0.14 (−15%) | |
| Liver | |||||
| Control | 1.90±0.06 | 1.68±0.01 | 0.11±0.03 | 1.13±0.05 | |
| IndoM | 1.70±0.05 (−11%) | 1.04±0.04* (−38%) | 0.07±0.02* (−36%) | 0.58±0.02* (−49%) | |
| Intestine | |||||
| Control | 5.90±0.20 | 7.52±0.04 | 3.35±0.23 | 9.74±0.93 | 22.90±0.92 |
| IndoM | 4.40±0.03* (−25%) | 5.30±0.02* (−30%) | 2.25±0.24* (−33%) | 7.81±0.68* (−20%) | 18.10±0.32* (−21%) |
Results are mean ± SEM of eight different preparations.
Values in parentheses represent percentage change from controls.
*
Significantly different at P < 0.05 from controls.