Table 5.
Effect of indomethacin (IndoM) on metabolic enzymes on different tissue homogenates.
| Tissues | Hexokinase (μmol/ mg protein/ h) | LDH (μmol/ mg protein/ h) | MDH (μmol/ mg protein/ h) |
|---|---|---|---|
| Cortex | |||
| Control | 30.76±1.24 | 6.56±0.19 | 40.80±0.79 |
| IndoM | 32.29±0.67 (+5%) | 8.82±0.95* (+34%) | 23.57±0.35* (−42%) |
| Medulla | |||
| Control | 20.89±0.65 | 10.24±0.23 | 21.10±0.26 |
| IndoM | 23.59±0.66 (+13%) | 12.96±0.12* (+27%) | 19.00±0.33 (−10%) |
| Liver | |||
| Control | 6.97±0.33 | 18.80±0.32 | 2.09±0.63 |
| IndoM | 7.85±0.32 (+13%) | 23.38±0.62* (+24%) | 1.33±0.22* (−36%) |
| Intestine | |||
| Control | 157.98±4.80 | 8.05±0.71 | 17.12±0.72 |
| IndoM | 132.20±3.20 (−16%) | 10.50±0.53* (+30%) | 10.50±0.44* (−39%) |
Results are mean ± SEM of eight different preparations.
Values in parentheses represent percentage change from controls.
*
Significantly different at P < 0.05 from controls.