Table 2.
Univariate and multivariate analysis of the association of NCKAP1 with survival and recurrence in patients with hepatocellular carcinoma
| Variables | OS | RFS | ||||
|---|---|---|---|---|---|---|
| Univariate | Multivariable analysis | Univariate | Multivariable analysis | |||
| P value | HR (95% CI) | P value | P value | HR (95% CI) | P value | |
| Age (yr) (≤50 versus >50) | 0.619 | 0.877 | ||||
| Gender (female versus male) | 0.678 | 0.981 | ||||
| Hepatitis B surface Ag (negative versus positive) | 0.796 | 0.713 | ||||
| Serum AFP (ng/mL) (<400 versus ≥400) | 0.026 | 0.020 | 1.674 (1.085–2.581) | 0.080 | ||
| Tumor size (cm) (≤5 versus>5) | 0.000 | 0.000 | 2.630 (1.620–4.268) | 0.000 | 0.000 | 2.719 (1.641–4.504) |
| Tumor number (solitary versus multiple) | 0.001 | 0.161 | 1.377 (0.880–2.153) | 0.000 | 0.042 | 1.594 (1.017–2.498) |
| PVTT (no versus yes) | 0.000 | 0.006 | 2.170 (1.252–3.762) | 0.000 | 0.060 | 1.704 (0.978–2.967) |
| Microvascular invasion (no versus yes) | 0.000 | 0.000 | 3.067 (1.896–4.960) | 0.000 | 0.000 | 2.922 (1.793–4.761) |
| Liver cirrhosis (no versus yes) | 0.047 | 0.021 | 0.596 (0.385–0.925) | 0.110 | ||
| Differentiation grade (I + II versus III + IV) | 0.036 | 0.114 | 1.397 (0.922–2.116) | 0.025 | 0.063 | 1.489 (0.978–-2.267) |
| NCKAP1 (negative versus positive) | 0.020 | 0.049 | 0.645 (0.417–0.997) | 0.041 | 0.234 | 0.766 (0.493–1.189) |
OS overall survival, RFS recurrence free survival, AFP alpha-fetoprotein, PVTT portal vein tumor thrombus, HR hazard ratio, CI confidence interval