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. 2019 May 8;9:7090. doi: 10.1038/s41598-019-43564-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Rhabdomyolysis has been associated with different conditions, including severe trauma, intense physical exercise, toxins and drugs. Regardless of its cause, myoglobin-induced renal toxicity by several factors: hypovolemia, nephrotoxicity in proximal tubule cells and myoglobin precipitation in distal tubule leading to tubular obstruction. As a consequence, increased oxidative damage and inflammation is observed in renal tissue with loss of renal function. All these damages were reduced with the treatment with calcitriol, this having an important role antioxidant and anti-inflammatory.