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. 2019 May 8;9:7089. doi: 10.1038/s41598-019-43607-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Replication of reduced tau and APP in CSF-derived microvesicles in AD. Microvesicles in the CSF of 14 AD patients and 9 controls were gated as shown in Fig. 1. The mean fluorescence intensities (MFI) for tau+ (A) and APP+ (B) microvesicles are shown for AD patients and controls. Differences between the groups were calculated with the non-parametric Mann-Whitney U Test. Receiver operating characteristics for both parameters are shown in (C) and (D). **p < 0.01.