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. 2019 May 8;9:7073. doi: 10.1038/s41598-019-43548-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Establishment of the molecular subtypes of Asian HCC. (A) The consensus map of the non-negative matrix factorization (NMF) clustering results in the training dataset of 150-TCGA samples. Subgroup1 and Subgroup2 were classified as molecular Subtype1 while subgroup3 was categorized as molecular Subtype2 according to the expression profiles of 185 HCC-characteristic genes. (B) The Kaplan-Meier plots comparing the overall survival (OS) (Left) and recurrence-free survival (RFS) (Right) of molecular Subtype1 and Subtype2 patients. P values were calculated by Log-rank tests.