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. 2019 May 8;9:7072. doi: 10.1038/s41598-019-43430-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Treatment with the Rho/MRTF pathway inhibitor CCG-222740 reduces viability and collagen production in cancer associated fibroblasts (CAFs) from Kras LSL-G12D; Trp53 LSL-R172H; Pdx1-Cre (KPC) mice. (A) CAFs were treated with several concentrations of CCG-222740 for 72 hours, and cell viability was determined by an MTT assay. (B,C) Cell cycle analysis of CAFs treated with 10 µM CCG-222740 (740) for 72 hours; ^#p = 0.09. (D) Protein levels of alpha smooth muscle actin (α-SMA), collagen 2 A (COL2A), collagen I (COL I) and collagen IV (COL IV) were determined in CAFs after treatment with CCG-222740 for 72 hours. Additional blots included in Supplemental Fig. 9.