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. 2019 May 8;9:7072. doi: 10.1038/s41598-019-43430-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Rho/MRTF pathway expression in human pancreatic cancer. (A) The Cancer Genome Atlas (TCGA) pancreatic cancer dataset was stratified into halves based upon predicted RhoA, RhoC or MRTFA activation (n = 83 per group). Kaplan–Meier plots were generated from the highest (black) and lowest (red) expressing halves. Survival curves were analyzed with the log-rank (Mantel-Cox) test with a cutoff of P < 0.05 as statistically significant. (B) Pearson correlation between MRTF signature and the immune cell signatures. A MRTF gene signature correlates with a Th2 cell gene signature in the PDA TCGA dataset.