Table 3.
Bacteria with known functional riboflavin biosynthesis pathways
| Phylum | Family or genus | Prevalence in AP lesions/% | Prevalence in control tissues/% |
|---|---|---|---|
| Actinobacteria | Corynebacterium | 42.9 | 50.0 |
| Bacteriodetes | Bacteroides | 3.6 | 0.0 |
| Prevotella | 57.1 | 67.9 | |
| Rikenellaceae | 25.0 | 10.7 | |
| Firmicutes | Streptococcus | 57.1 | 78.6 |
| Anaerococcus | 10.7 | 14.3 | |
| Erysipelotrichaceae | 3.6 | 3.6 | |
| Fusobacteria | Fusobacterium | 71.4 | 75.0 |
| Proteobacteria | Ralstonia | 14.3 | 17.9 |
| Bilophila | 3.6 | 0.0 | |
| Desulfovibrio | 7.1 | 0.0 | |
| Campylobacter | 39.3 | 42.9 | |
| Enterobacteriaceae | 85.7 | 82.1 | |
| Acinetobacter | 3.6 | 3.6 | |
| Synergistetes | Fretibacterium | 42.9 | 39.3 |
All AP lesions and control tissue contained multiple bacterial taxa that are predicted to have functional riboflavin biosynthesis pathways, specifically containing a 6,7-dimethyl-8-ribityllumazine (RL-6,7-diMe) synthase gene (EC 2.5.1.78) required for the production of the main MR1-binding ligand RL-6,7-diMe11,52