Table 1.
Clinicopathological characteristics based on methylated septin 9 status in 300 colorectal cancer patients
| Parameter | Positive group (%) | Negative group (%) | P | |
| Gender | Male | 84 (28.0) | 81 (27.0) | 0.585 |
| Female | 73 (24.3) | 62 (20.7) | ||
| Age | ≤ 50 yr | 45 (15.0) | 60 (20.0) | 0.016 |
| > 50 yr | 112 (37.3) | 83 (27.7) | ||
| UICC stage | I | 9 (3.0) | 20 (6.7) | 0.020 |
| II | 46 (15.3) | 32 (10.7) | ||
| III | 62 (20.6) | 71 (23.7) | ||
| IV | 13 (4.3) | 6 (2.0) | ||
| Unknown | 27 (9.0) | 14 (4.7) | ||
| Histologic grade | Low level | 115 (38.3) | 103 (34.3) | 0.972 |
| High level | 18 (6.0) | 17 (5.7) | ||
| Not recorded | 24 (8.0) | 23 (7.7) | ||
| Primary tumor (T) category | T1 | 2 (0. 7) | 3 (1.0) | 0.002 |
| T2 | 15 (5.0) | 23 (7.7) | ||
| T3 | 70 (23.3) | 67 (22.3) | ||
| T4 | 40 (13.3) | 34 (11.3) | ||
| Not recorded | 30 (10.0) | 16 (5.3) | ||
| Regional node (N) category | N0 | 57 (19.0) | 23 (7.7) | 0.852 |
| N1 | 32 (10.7) | 67 (22.3) | ||
| N2 | 37 (12.3) | 34 (11.3) | ||
| Not recorded | 31 (10.3) | 16 (5.3) | ||
| Distant metastasis (M) | Absent | 141 (47.0) | 137 (45.7) | 0.015 |
| Present | 16 (5.3) | 6 (2.0) | ||
| Lymphatic invasion (L) | Absent | 58 (19.3) | 60 (20.0) | 0.217 |
| Present | 51 (17.0) | 52 (17.3) | ||
| Not recorded | 48 (16.0) | 31 (10.3) | ||
| Lymph nodal status | No node involved | 51 (17.0) | 52 (17.3) | 0.048 |
| 1-3 lymph node involved | 27 (9.0) | 40 (13.3) | ||
| > 4 lymph node involved | 31 (10.3) | 20 (6.7) | ||
| Not recorded | 48 (16) | 31 (10.3) | ||
| Vascular invasion (V) | Absent | 36 (12.0) | 31 (10.3) | 0.278 |
| Present | 70 (23.3) | 76 (25.3) | ||
| Not recorded | 51 (17.0) | 36 (12.0) | ||
| Tumor sitea | Left colon | 44 (14.7) | 31 (10.3) | 0.022 |
| Right colon | 27 (9.0) | 11 (3.7) | ||
| Rectum | 74 (24.7) | 86 (28.6) | ||
| Unable to distinguish | 12 (4.0) | 15 (5.0) |
a
Right colon includes cecum through transverse colon, whereas left colon includes splenic flexure, descending colon, and sigmoid colon. Clinicopathological characteristics between positive group and negative group were analyzed using χ2 test. UICC: Union for International Cancer Control.