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. 2019 May 8;9:7096. doi: 10.1038/s41598-019-43275-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Platelet activation in patients with dengue infection or HIV plus dengue coinfection: Activation was assessed at the febrile, defervescence and recovery phases of dengue illness in freshly isolated platelets from patients with dengue only or coinfected with HIV and dengue (HIV + dengue). (A) The percentage of platelets with P-selectin (CD62P) surface expression in each condition; and (B) the fluorescence of the probe DAF-FM diacetate indicating NO synthesis by platelets. The horizontal lines in the box plots represent the median, the box edges represent the interquartile ranges and the whiskers indicate 5–95 percentile. *Signifies p < 0.05 compared to patients with the same profile of infection (dengue or HIV + dengue) at the recovery. ^#Means p < 0.05 between dengue and HIV + dengue infected patients.